JPH047346B2 - - Google Patents

Info

Publication number
JPH047346B2
JPH047346B2 JP58084864A JP8486483A JPH047346B2 JP H047346 B2 JPH047346 B2 JP H047346B2 JP 58084864 A JP58084864 A JP 58084864A JP 8486483 A JP8486483 A JP 8486483A JP H047346 B2 JPH047346 B2 JP H047346B2
Authority
JP
Japan
Prior art keywords
formula
carbon atoms
compound
alkyl
add
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58084864A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58213771A (ja
Inventor
Buruusu Gamiru Ronarudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of JPS58213771A publication Critical patent/JPS58213771A/ja
Publication of JPH047346B2 publication Critical patent/JPH047346B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58084864A 1982-05-17 1983-05-13 フラン酸を用いる抗アテローム性動脈硬化症フロクロモンの製造用中間体の製法 Granted JPS58213771A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/378,687 US4434296A (en) 1982-05-17 1982-05-17 Process for preparing intermediates for antiatherosclerotic compounds
US378687 1995-01-26

Publications (2)

Publication Number Publication Date
JPS58213771A JPS58213771A (ja) 1983-12-12
JPH047346B2 true JPH047346B2 (en]) 1992-02-10

Family

ID=23494134

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58084864A Granted JPS58213771A (ja) 1982-05-17 1983-05-13 フラン酸を用いる抗アテローム性動脈硬化症フロクロモンの製造用中間体の製法

Country Status (4)

Country Link
US (1) US4434296A (en])
EP (1) EP0095835B1 (en])
JP (1) JPS58213771A (en])
DE (1) DE3367386D1 (en])

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609739A (en) * 1984-11-06 1986-09-02 The Upjohn Company Synthetic routes to benzofurans and benzothiophenes and intermediates therefor
US4623737A (en) 1984-12-07 1986-11-18 The Upjohn Company Synthesis of precursors of anti-atherosclerotic furochromones
US4758676A (en) * 1984-12-07 1988-07-19 The Upjohn Company Intermediates for antiatherosclerotic furochromones
DK1511734T3 (da) * 2002-04-17 2010-08-02 Cytokinetics Inc Forbindelser, præparater og fremgangsmåder
AU2003252025A1 (en) * 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003267169A1 (en) * 2002-09-13 2004-04-30 Cytokinetics, Inc. Compounds, compositions and methods
EP1670456A2 (en) * 2003-10-06 2006-06-21 Cytokinetics, Inc. Compounds, compositions and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680119A (en) 1949-08-20 1954-06-01 Smith Kline French Lab Method for the production of khellin and related compounds
US4284569A (en) 1979-02-13 1981-08-18 The Upjohn Company Antiatherosclerotic furochromones

Also Published As

Publication number Publication date
EP0095835B1 (en) 1986-11-05
DE3367386D1 (en) 1986-12-11
JPS58213771A (ja) 1983-12-12
EP0095835A1 (en) 1983-12-07
US4434296A (en) 1984-02-28

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